Supplementary Table 3.

Genotype distributions in controls and AD cases of seven centres

Gene	SNP	Centre	Controls			AD
PPARA	rs135551 = Intron 2 G/A		GG	GA	AA	GG	GA	AA
		Bonn	103	88	31	109	114	21
		Bristol	21	26	4	99	71	20
		Nottingham	48	48	3	57	31	7
		OPTIMA	134	94	21	133	99	15
		Oviedo	58	45	8	91	70	17
		Rotterdam	2707	2005	398	200	159	32
		Santander	208	134	25	177	127	17
		Totals	3279	2440	490	866	671	129
PPARA	rs1800206 = L162V		LL = CC	LV = CG	VV = GG	LL = CC	LV = CG	VV = GG
		Bonn	186	24	1	217	27	1
		Bristol	41	15	0	169	24	6
		Nottingham	87	11	0	77	9	0
		OPTIMA	203	39	1	208	28	3
		Oviedo	99	21	4	165	31	1
		Rotterdam	4393	590	22	341	46	1
		Santander	314	60	2	281	36	6
		Totals	5323	760	30	1458	201	18
PPARA	rs4253766 = Intron 6 C/T		CC	TC	TT	CC	TC	TT
		Bonn	183	42	3	197	53	3
		Bristol	47	8	1	160	39	0
		Nottingham	76	19	2	71	13	2
		OPTIMA	199	44	3	198	41	3
		Oviedo	90	31	1	154	42	1
		Rotterdam	4044	1007	59	320	68	3
		Santander	298	84	4	271	64	2
		Totals	4937	1235	73	1371	320	14
IL1A	rs3783550 = Intron 6 A/C		AA	AC	CC	AA	AC	CC
		Bonn	115	94	22	124	100	31
		Bristol	25	27	4	89	86	20
		Nottingham	44	44	6	42	29	12
		OPTIMA	115	107	24	117	95	29
		Oviedo	65	44	7	89	84	19
		Rotterdam	2415	2195	500	194	162	35
		Santander	186	167	39	180	115	34
		Totals	2965	2678	602	835	671	180
IL1B	rs16944 = -971 G/A		GG	GA	AA	GG	GA	AA
		Bonn	98	99	22	112	102	31
		Bristol	22	20	8	82	81	27
		Nottingham	49	30	14	32	32	15
		OPTIMA	106	114	27	91	114	33
		Oviedo	50	56	11	79	84	27
		Rotterdam	2216	2309	585	171	180	40
		Santander	160	181	36	151	131	27
		Totals	2701	2809	703	718	724	200
IL10	rs1800896 = -1082 G/A		GG	AG	AA	GG	AG	AA
		Bonn	45	109	62	54	118	73
		Bristol	12	25	15	45	72	45
		Nottingham	22	29	25	21	28	18
		OPTIMA	58	123	60	72	112	53
		Oviedo	25	61	24	24	97	65
		Rotterdam	1339	2538	1233	120	190	81
		Santander	66	185	136	38	182	91
		Totals	1567	3070	1555	374	799	426