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. 2012 Feb 5;3(1):1–17.

Table 2.

Association of tag and previously reported risk-associated SNPs in nucleotide excision repair genes with lung cancer risk among non-Hispanic white participants

  No. of cases No. of controls
 
SNP Gene Major Allele (A1) Minor Allele (A2) MAFa A1/A1 A1/A2 A2/A2 A1/A1 A1/A2 A2/A2 OR per A2 (95% CI)b p-trend
rs735482 ERCC1 A C 14.3% 564 165 15 1086 360 31 0.90 (0.75-1.08) 0.252
rs3212986 ERCC1 C A 25.5% 418 284 41 829 537 107 0.97 (0.84-1.11) 0.634
rs16979802c ERCC1 G C 8.1% 642 99 3 1253 210 14 0.85 (0.67-1.08) 0.192
rs11615 ERCC1 T C 38.3% 289 359 96 585 653 239 0.95 (0.84-1.08) 0.451
rs2298881 ERCC1 C A 10.6% 609 124 11 1183 273 20 0.91 (0.74-1.12) 0.379
rs10853773 ERCC2 G A 28.2% 386 304 53 761 594 118 0.98 (0.85-1.12) 0.742
rs13181 ERCC2 A C 37.2% 310 330 102 585 681 207 0.95 (0.83-1.08) 0.437
rs1799787 ERCC2 G A 30.8% 366 304 71 700 639 134 0.97 (0.84-1.11) 0.623
rs238417 ERCC2 G C 40.8% 254 351 136 513 719 242 1.05 (0.92-1.19) 0.449
rs238416 ERCC2 G A 34.7% 307 333 103 628 668 178 1.07 (0.93-1.21) 0.339
rs50872 ERCC2 G A 23.6% 433 261 47 851 554 71 1.02 (0.88-1.18) 0.813
rs50871 ERCC2 A C 48.2% 166 389 188 400 726 346 1.15 (1.01-1.30) 0.029
rs238404 ERCC2 A G 44.5% 218 354 167 450 727 289 1.08 (0.95-1.23) 0.218
rs1799793 ERCC2 G A 35.5% 326 329 89 610 685 182 0.93 (0.82-1.07) 0.316
rs238406 ERCC2 G T 43.6% 228 357 159 461 745 271 1.07 (0.95-1.22) 0.275
rs3810366 ERCC2 C G 45.4% 245 353 144 431 744 295 0.92 (0.81-1.04) 0.193
rs1803541 ERCC3 G A 4.0% 681 58 4 1355 113 2 1.09 (0.80-1.48) 0.580
rs4150506 ERCC3 G A 22.1% 449 255 37 894 511 71 1.00 (0.86-1.16) 0.995
rs4150471 ERCC3 G A 29.6% 388 293 62 725 623 125 0.93 (0.81-1.07) 0.316
rs4150454 ERCC3 A G 38.8% 259 359 121 555 690 225 1.08 (0.95-1.23) 0.235
rs4150403 ERCC3 G A 8.9% 638 104 2 1223 243 10 0.81 (0.64-1.02) 0.078
rs1799797 ERCC4 T A 26.7% 391 295 58 796 574 107 1.05 (0.92-1.21) 0.461
rs1800067 ERCC4 G A 7.1% 635 101 7 1273 199 5 1.09 (0.86-1.39) 0.465
rs3136166 ERCC4 T G 34.2% 320 340 84 636 672 169 1.00 (0.88-1.14) 0.980
rs1799801c ERCC4 A G 28.3% 380 302 60 763 592 121 1.02 (0.88-1.17) 0.816
rs2018836c ERCC5 G A 31.1% 361 320 62 705 624 147 0.95 (0.83-1.09) 0.444
rs2296147 ERCC5 A G 47.8% 182 385 174 407 723 341 1.07 (0.94-1.21) 0.309
rs7325708 ERCC5 G C 18.3% 497 225 21 985 439 50 0.97 (0.83-1.15) 0.749
rs1047768 ERCC5 G A 41.1% 256 378 108 507 722 245 0.96 (0.84-1.09) 0.498
rs1047769c ERCC5 A G 3.8% 694 45 1 1359 111 1 0.80 (0.56-1.14) 0.214
rs2227869 ERCC5 C G 3.9% 680 63 1 1362 110 2 1.15 (0.84-1.59) 0.374
rs3759500 ERCC5 G A 23.0% 445 260 37 879 513 82 0.98 (0.84-1.14) 0.798
rs4150351 ERCC5 A C 17.0% 499 221 22 1016 417 42 1.07 (0.90-1.26) 0.452
rs4150355 ERCC5 G A 37.6% 277 375 90 584 672 219 0.98 (0.86-1.12) 0.819
rs732321c ERCC5 A C 3.9% 680 63 1 1364 111 2 1.14 (0.83-1.56) 0.409
rs4150386 ERCC5 A C 12.8% 589 150 5 1120 330 24 0.83 (0.68-1.01) 0.060
rs17655c ERCC5 G C 21.2% 454 261 29 919 489 68 1.01 (0.87-1.18) 0.856
rs873601 ERCC5 A G 27.1% 392 299 51 783 584 107 1.00 (0.87-1.15) 0.990
rs4150393 ERCC5 A G 11.1% 567 168 6 1166 291 19 1.10 (0.90-1.34) 0.347
rs274883 LIG1 A G 18.1% 523 192 29 996 424 55 0.91 (0.77-1.07) 0.247
rs3731014 LIG1 G A 12.3% 595 138 11 1139 311 26 0.85 (0.70-1.03) 0.102
rs3731007 LIG1 G A 5.7% 656 86 2 1311 158 5 1.07 (0.82-1.39) 0.630
rs156640 LIG1 C G 41.0% 217 366 157 499 741 233 1.23 (1.08-1.40) 0.001
rs156641 LIG1 G A 35.3% 271 352 121 596 709 164 1.23 (1.08-1.40) 0.002
rs754948 LIG1 C T 4.6% 684 59 1 1345 128 4 0.89 (0.66-1.22) 0.474
rs4987068c LIG1 G A 2.1% 699 44 0 1411 63 0 1.40 (0.94-2.08) 0.100
rs3730931c LIG1 A G 12.4% 595 137 11 1137 313 26 0.84 (0.69-1.02) 0.081
rs20580 LIG1 C A 47.9% 175 381 184 395 744 334 1.11 (0.98-1.26) 0.111
rs8100261 LIG1 G A 48.3% 227 368 147 396 734 347 0.86 (0.76-0.98) 0.023
rs20579c LIG1 G A 13.0% 583 141 18 1126 312 36 0.90 (0.75-1.09) 0.278
rs14302 POLE C T 41.1% 263 336 144 535 668 272 1.04 (0.92-1.17) 0.551
rs5745066 POLE G A 2.1% 709 34 1 1412 63 0 1.11 (0.73-1.68) 0.634
rs7963858 POLE C T 31.8% 340 332 72 690 635 152 1.02 (0.89-1.16) 0.809
rs5744990 POLE G A 16.1% 512 210 22 1039 400 37 1.08 (0.91-1.28) 0.374
rs5744941 POLE A T 8.7% 612 127 5 1230 237 10 1.07 (0.86-1.33) 0.564
rs5744857 POLE G A 44.9% 246 362 143 448 723 299 0.92 (0.81-1.05) 0.211
rs5744807 POLE A G 4.1% 691 50 2 1356 116 2 0.88 (0.64-1.23) 0.463
rs5744799c POLE A T 1.7% 726 18 0 1427 49 0 0.74 (0.43-1.29) 0.287
rs5744769 POLE C G 13.7% 551 181 12 1098 354 25 1.00 (0.83-1.20) 0.991
rs5744761 POLE G A 4.5% 676 66 1 1345 129 2 1.01 (0.75-1.37) 0.921
rs11147005 POLE A G 31.1% 375 300 66 703 627 145 0.91 (0.80-1.05) 0.189
rs3176757 XPA G A 19.8% 473 239 32 944 479 52 1.04 (0.89-1.22) 0.610
rs3176748 XPA A G 31.5% 335 332 63 679 620 145 0.99 (0.86-1.14) 0.898
rs2808667 XPA G A 6.6% 657 83 1 1282 178 8 0.85 (0.65-1.10) 0.220
rs2805835 XPA G C 11.3% 597 141 5 1159 301 17 0.89 (0.73-1.10) 0.290
rs3176689 XPA A T 16.8% 518 203 23 1024 409 43 0.99 (0.84-1.17) 0.902
rs3176683 XPA A G 6.7% 662 77 1 1284 185 7 0.77 (0.59-1.01) 0.056
rs3176658 XPA G A 13.9% 581 148 14 1094 348 31 0.83 (0.69-1.00) 0.055
rs3176633 XPA C G 15.0% 552 173 19 1064 384 29 0.94 (0.79-1.13) 0.511
rs1800975 XPA G A 33.8% 320 326 71 622 621 166 0.95 (0.83-1.09) 0.452
rs1126547 XPC G C 13.3% 551 184 9 1105 351 21 1.02 (0.85-1.23) 0.815
rs2228001 XPC A C 39.8% 263 379 100 520 739 218 0.96 (0.85-1.10) 0.594
rs3731124 XPC A C 24.2% 424 276 44 847 545 84 1.00 (0.87-1.16) 0.973
rs2607737 XPC G A 48.5% 177 395 168 381 751 338 1.03 (0.91-1.17) 0.624
rs9653966 XPC A C 8.4% 631 104 9 1236 231 8 0.99 (0.79-1.24) 0.921
rs1124303 XPC T G 8.0% 626 114 4 1252 214 11 1.02 (0.81-1.28) 0.848
rs3731143 XPC A G 6.1% 648 91 5 1307 161 9 1.14 (0.89-1.46) 0.295
rs2228000 XPC G A 25.1% 401 299 43 822 566 87 1.06 (0.91-1.22) 0.451
rs2733537 XPC A G 33.4% 320 337 84 638 684 150 1.05 (0.91-1.20) 0.515
a

Minor allele frequency among controls;

b

Adjusted for age, sex, smoking status, occupational asbestos exposure, and enrollment year;

c

non-tag SNP