Table 4.

Relation of LIG1 haplotypes and diplotypes and XPA haplotypes to lung cancer risk in non- Hispanic white participants

LIG1 Haplotypes
rs274883	rs3731014	rs3731007	rs156640	rs156641	rs754948	rs20580	rs8100261		Cases (%)	Controls (%)	OR (95% CI)a
A	G	G	C	G	C	C	A		43.1	46.3	1.00 (reference)
A	G	G	G	A	C	A	G		39.7	35.0	1.22 (1.06-1.41)
G	A	G	C	G	C	A	G		9.3	10.4	0.95 (0.76-1.18)
G	G	A	G	G	T	C	G		3.9	4.4	0.97 (0.70-1.35)
G	A	G	C	G	C	A	A		1.4	1.8	0.79 (0.47-1.33)
G	G	A	G	G	C	C	G		1.9	1.1	1.88 (1.13-3.14)
*	*	*	*	*	*	*	*		0.7	1.0	0.71 (0.30-1.70)
									global p-value = 0.008
LIG1 Diplotypes									Cases (n)	Controls (n)	OR (95% CI)a
rs156640			rs156641			rs8100261
CC			GG			AA			146	340	1.00 (reference)
CG			AG			AG			267	523	1.17 (0.92-1.50)
GG			AA			GG			119	163	1.69 (1.24-2.30)
CC			GG			AG			61	137	1.00 (0.70-1.44)
CG			AG			GG			47	118	0.92 (0.62-1.35)
CG			GG			AG			38	69	1.27 (0.81-1.98)
GG			AG			GG			35	65	1.24 (0.79-1.96)
Other genotype combinations									25	50	1.14 (0.68-1.92)
XPA Haplotypes									Cases (%)	Controls (%)	OR (95% CI)a
rs3176757	rs3176748	rs2808667	rs2805835	rs3176689	rs3176683	rs3176658	rs3176633	rs1800975
G	G	G	G	A	A	G	C	G	31.6	31.7	1.00 (reference)
G	A	G	G	T	A	G	C	G	16.7	16.7	1.00 (0.83-1.21)
G	A	G	C	A	A	G	C	G	10.2	11.3	0.92 (0.73-1.15)
G	A	G	G	A	A	G	C	G	9.1	6.3	1.47 (1.14-1.91)
G	A	G	G	A	A	A	C	A	6.1	7.2	0.86 (0.65-1.13)
G	A	A	G	A	A	A	C	A	5.7	6.5	0.89 (0.68-1.18)
A	A	G	G	A	A	G	C	A	6.4	5.0	1.31 (0.99-1.75)
A	A	G	G	A	A	G	G	A	8.6	8.0	1.08 (0.85-1.38)
A	A	G	G	A	G	G	G	A	5.4	6.7	0.79 (0.60-1.06)
*	*	*	*	*	*	*	*	*	0.2	0.6	0.97 (0.17-5.68)
									global p-value = 0.01

^aAdjusted for age, sex, smoking status, occupational asbestos exposure, and enrollment year