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. 2012 Mar 30;7(3):e32293. doi: 10.1371/journal.pone.0032293

Figure 9. Inhibition of WT presenilin 1 and FAD mutants by DAPT and L-685,458.

Figure 9

CHAPSO enriched γ-secretase membranes carrying WT presenilin 1 or FAD mutations ΔE9 and G384A have been prepared and analyzed in parallel with all conditions identical. The dose response curves for DAPT [71] and L-685,458 [15] were measured by following total AICD production using western-blots with αM2 antiflag antibody as shown in Fig. 3. The results were analyzed using nonlinear regression and the equation 3 (methods). The best fit values and the corresponding statistics are given in Table 3.