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. 2012 Mar 30;7(3):e32995. doi: 10.1371/journal.pone.0032995

Figure 6. Significant correlation between STAT1 and GAC mRNA levels in brain tissues of HAD patients.

Figure 6

Total RNA from post-mortem brain tissue collected from HAD patients, HIV serum-positive patients without dementia, and HIV serum negative individuals were extracted and subjected to real time RT-PCR for STAT1, GAC, IFN-α2 and IFN-β. GAPDH expression was used as an internal control. (A) Levels of STAT1 are normalized as a ratio to GAPDH and shown as fold change relative to the average of HIV serum negative controls. Results are shown as the average ± SEM, #, p<0.05. Correlation of GAC with STAT1 (B), IFN-α2 (C) and IFN-β (D) mRNA levels was determined by Spearman correlation.