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. 2012 Mar 30;7(3):e33066. doi: 10.1371/journal.pone.0033066

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Mariotti et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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In the figure, the SPS2 genes found in some representative species are shown. The positions of introns along the protein sequence are displayed with black lines, and the Sec residue is displayed in red. In a few cases, the predicted genes were incomplete because of poor sequence data (e.g., the N-terminal region in platypus). Placental mammals (bottom) possess a single intronless gene, SPS2b. Non-mammalian vertebrates (top) and platypus possess a single multiexon gene, SPS2a. Marsupials (opossum and wallaby) possess both.