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. 2012 Mar 30;7(3):e33565. doi: 10.1371/journal.pone.0033565

Figure 3. Conserved features across exon 7/7a/7b of GFAP.

Figure 3

The profile shows detail of the Group 2 profile from Figure 2 in the region surrounding exons 7 (right of screen) and 7a (right of centre). Exons (wide bars), UTRs (narrow bars) and introns (arrowed lines) are shown for two genes in the UCSC collection and one in RefSeq. At the bottom is the UCSC conservation profile relative to mouse and rat. Conserved regions are labelled A–F (in white). Labelling is from right to left to match the order in which exons are displayed. Conserved motifs that were identified are labelled as follows: GGG, the 3G triplets (feature A); EBF1, motif recognized by the transcription factor EBF1 (feature B); HSF1 and HSF2, the actual and possible acceptor sites identified by Human Splice Finder (scores 93.19 and 76.63 respectively, feature C); PTB1 (feature D) and PTB2 (feature C), conserved PTB-binding motifs embedded in polypyrimidine-rich sequences; PolyA polyadenylation signal AAUAAA (feature E). All other symbols are as per Figure 2.