Table 1. Selected genes induced 3-fold or above by amicoumacin A.
COL ORF | Fold induction | Gene product | |||
T10 | T40 | ||||
Cell envelope | |||||
SACOL0248a | 14.0 | 1.4 | LrgB, antiholin | ||
SACOL0247a | 8.6 | 1.0 | LrgA, murein hydrolase regulator | − | |
SACOL2197 | 9.2 | 11.9 | Surface protein | + | σB |
SACOL2557 | 4.3 | 2.7 | N-acetylmuramoyl-L-alanine amidase | ||
SACOL1062 | 3.9 | 4.0 | Atl, bifunctional autolysin | + | σB |
SACOL0671b | 3.9 | 2.2 | α/β-fold family hydrolase | + | σB |
SACOL2597 | 3.5 | 1.4 | α/β-fold family hydrolase | + | σB |
SACOL2019 | 3.8 | 3.3 | SdrH protein | − | |
SACOL2434 | 3.0 | 3.2 | cell surface polysaccharide synthesis | + | σB |
Transporter | |||||
SACOL2138c | 6.7 | 7.8 | Cation efflux family protein | ||
SACOL2136c | 4.1 | 1.4 | Hypothetical | σB | |
SACOL0264 | 4.0 | 4.5 | ABC transporter | ||
SACOL2176 | 3.8 | 2.2 | OpuD2, osmoprotectant transporter | + | σB |
SACOL0681d | 3.3 | 3.5 | monovalent cation/H+ antiporter C | σB | |
SACOL0679d | 3.1 | 2.8 | monovalent cation/H+ antiporter A | σB | |
SACOL0682d | 3.0 | 3.1 | monovalent cation/H+ antiporter D | σB | |
SACOL0680d | 3.0 | 3.1 | monovalent cation/H+ antiporter B | σB | |
SACOL1422 | 3.1 | 3.7 | phosphate ABC transporter | ||
Virulence | |||||
SACOL2295 | 5.5 | 7.2 | Staphyloxanthin biosynthesis | ||
SACOL0136e | 3.8 | 2.7 | Cap5A, capsular polysaccharide biosynthesis | σB | |
SACOL0137e | 3.0 | 2.3 | Cap5B, capsular polysaccharide biosynthesis | σB | |
SACOL0138e | 3.4 | 2.0 | Cap5C, capsular polysaccharide biosynthesis | σB | |
SACOL0672b | 3.4 | 2.0 | SarA, staphylococcal accessory regulator | + | |
SACOL0856 | 3.3 | 3.0 | clumping factor | + | σB |
SACOL2511 | 3.0 | 5.4 | fibronectin-binding protein |
Superscript alphabet indicates genes in the same operon. + and − arrows show genes induced or repressed in response to linoleic acid based on [25]. σB-controlled genes are marked.