Table 2. Codon substitution mutations found in amicoumacin-A-resistant COL.
Isolate | Fold-resistance | Mutated gene (mutation) | Function |
SA-1 | 2 | SACOL0187 (D343H) | RGD-containing lipoprotein |
SA-3 | 8 | fusA (G530V) | Elongation factor G |
oppB (I263F) | Oligopeptide permease | ||
dnaG (R190H) | DNA primase | ||
SA-6 | 16 | fusA (G531S) | Elongation factor G |
ksgA (L260Stp) | 16 S rRNA methyl transferase | ||
lacD (G86R) | tagatose-1,6-bisphosphate aldolase | ||
SACOL0611 (S472P) | Glycosyl transferase |