Table 1. Type I and Type II functional divergence between the NPSR and vasopressin-like receptor subtypes.

Divergence	Comparison	θ±SE	z	TM	ECL	ICL
Type I	NPSR . V1AR	0.74±0.07	10.22	11	5	2
	NPSR . V1BR	0.52±0.07	7.84	3	3	6
	NPSR . V2R	0.51±0.07	7.65	5	4	1
	NPSR . OTR	0.63±0.07	9.20	5	1	3
Type II	NPSR . V1AR	0.53±0.06	9.04	12	8	3
	NPSR . V1BR	0.44±.007	6.42	10	6	2
	NPSR . V2R	0.49±.07	6.48	11	3	-
	NPSR . OTR	0.54±0.05	10.4	21	10	1

Note: θ denotes the coefficient of functional divergence. SE is standard error. z score is the value of confidence and is obtained by θ/SE. P value is the probability of the z score, which had a value of <0.0001 in all comparisons. The symbol - indicates the absence of divergent sites. Abbreviations: TM – Transmembrane helices, ECL – Extracellular loops, ICL – Intracellular loops.