Figure 6 .

Model of EPA1 regulation. In stationary phase (SP), EPA1 is not expressed and cells are nonadherent. Upon dilution into fresh media, (1) a log-phase specific transcriptional activator (LP-Ac) induces expression of EPA1 and cells become adherent. This transcriptional activation is counteracted in log phase (LP) by the concerted action of silencing and the NE (2). The Sir complex silences the expression of EPA1 and yKu70/yKu80 repress EPA1 expression through the NE. These two regulatory mechanisms assure that EPA1 is not expressed even in the presence of the LP-Ac, which is active throughout LP.