Table 1 . Strains used in this study.

Strain	Parent	Genotype	Reference
Escherichia coli strain
DH10B		F− mcrA Δ(mrr-hsdRMS-mcrBC) Φ80dlacZΔM15 ΔlacX74 deoR recA1 endA1 araD139 Δ(ara,leu)7697galU galK λ− rpsL nupG	Calvin and Hanawalt (1988)
Candida glabrata strains
BG2		Clinical isolate (strain B)	Fidel et al. (1996)
BG14	BG2	ura3Δ::Tn903 G418R	Cormack and Falkow (1999)
BG64	BG14	epa1Δ ura3Δ::Tn903 G418R	Cormack et al. (1999)
BG198	BG14	ura3Δ::Tn903 G418R epa1Δ::GFP. GFP under the control of the EPA1 promoter (Figure 1C)	De Las Peñas et al. (2003)
BG201	BG14	ura3Δ::Tn903 G418R epa1Δ::GFP pYIplac211 integrated 300bp from TAA of EPA1. GFP under the control of the EPA1 promoter (Figure 1C)	This work
BG509	BG14	ura3Δ::Tn903 G418R rif1Δ::hph HygR	Castaño et al. (2005)
BG592	BG14	ura3Δ::Tn903 G418R rap1-21	De Las Peñas et al. (2003)
BG646	BG14	ura3Δ::Tn903 G418R Tn7 at intergenic region between EPA1 and EPA2	De Las Peñas et al. (2003)
BG676	BG14	ura3Δ::Tn903 G418R sir3Δ::hph HygR	De Las Peñas et al. (2003)
BG1048	BG14	ura3Δ::Tn903 G418R sir2Δ::hph HygR	Domergue et al. (2005)
BG1050	BG14	ura3Δ::Tn903 G418R sir4Δ::hph HygR	Rosas-Hernandez et al. (2008)
BG1080	BG14	ura3Δ::Tn903 G418R hdf1Δ::hph HygR	Rosas-Hernandez et al. (2008)
BG1081	BG14	ura3Δ::Tn903 G418R hdf2Δ::hph HygR	Rosas-Hernandez et al. (2008)
BG1124	BG1212	ura3Δ::Tn903 G418R epa1Δ::URA3. EPA1 replaced by URA3. URA3 under the control of the EPA1 promoter	This work
BG1132	BG14	ura3Δ::Tn903 G418R epa1Δ::URA3 neΔ::cat. EPA1 replaced by URA3 and NE (negative element) replaced by the bacterial cat gene, chloramphenicol acetyl transferase from pACYC184 URA3 under the control of the EPA1 promoter	This work
sir2Δ
CGM172	BG1124	ura3Δ::Tn903 G418R epa1Δ::URA3 sir2Δ::hph HygR	This work
CGM174	BG1132	ura3Δ::Tn903 G418R epa1Δ::URA3 neΔ::cat sir2Δ::hph HygR	This work
sir3Δ
CGM283	BG1124	ura3Δ::Tn903 G418R epa1Δ::URA3 sir3Δ::hph HygR	This work
CGM285	BG1132	ura3Δ::Tn903 G418R epa1Δ::URA3 neΔ::cat sir3Δ::hph HygR	This work
sir4Δ
CGM188	BG1124	ura3Δ::Tn903 G418R epa1Δ::URA3 sir4Δ::hph HygR	This work
CGM190	BG1132	ura3Δ::Tn903 G418R epa1Δ::URA3 neΔ::cat sir4Δ::hph HygR	This work
hdf1Δ
CGM198	BG1124	ura3Δ::Tn903 G418R epa1Δ::URA3 hdf1Δ::hph HygR	This work
CGM184	BG1132	ura3Δ::Tn903 G418R epa1Δ::URA3 neΔ::cat hdf1Δ::hph HygR	This work
hdf2Δ
CGM187	BG1124	ura3Δ::Tn903 G418R epa1Δ::URA3 hdf2Δ::hph HygR	This work
CGM185	BG1132	ura3Δ::Tn903 G418R epa1Δ::URA3 neΔ::cat hdf2Δ::hph HygR	This work
rif1Δ
CGM210	BG1124	ura3Δ::Tn903 G418R epa1Δ::URA3 rif1Δ::hph HygR	This work
CGM212	BG1132	ura3Δ::Tn903 G418R epa1Δ::URA3 neΔ::cat rif1Δ::hph HygR	This work
hst1Δ
CGM213	BG1124	ura3Δ::Tn903 G418R epa1Δ::URA3 hst1Δ::hph HygR	This work
CGM214	BG1132	ura3Δ::Tn903 G418R epa1Δ::URA3 neΔ::cat hst1Δ::hph HygR	This work
hst2Δ
CGM208	BG1124	ura3Δ::Tn903 G418R epa1Δ::URA3hst2Δ::hph HygR	This work
CGM217	BG1132	ura3Δ::Tn903 G418R epa1Δ::URA3 neΔ::cathst2Δ::hph HygR	This work
rap1-21
CGM349	BG592	ura3Δ::Tn903 G418R rap1-21 epa1Δ::URA3	This work
CGM374	BG592	ura3Δ::Tn903 G418R rap1-21 epa1Δ::URA3 neΔ::cat	This work