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. 2012 Mar 30;7(3):e34494. doi: 10.1371/journal.pone.0034494

Figure 7. Abrogation of NO production after anti-bacteria and/or NOS inhibition in BIA, CIA and BIA-CIA mice.

Figure 7

A. Serum NO levels in drug-administered BIA, CIA and BIA-CIA mice (n = 3). The serum NO level was determined after anti-bacteria and/or NOS inhibition of modeling mice by 60 µg/ml artesunate, 50 µg/ml rapamycin, 15% alcohol or a combination of drugs; B. Serum NO levels in bacteria-fed or antibiotic-administered mice (n = 10). The serum NO level was determined after live bacterial feeding for 7 d and injecting artesunate, cefotaxime, or the combination of artesunate with cefotaxime for 3 d (twice a day). ART: artesunate; CEF: cefotaxime; RAP: rapamycin; ALC: alcohol. The singular asterisk (*) represents statistically significant difference from the control (P<0.05); and double asterisks (**) indicate statistically very significant difference from the control (P<0.01).