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. 2012 Mar 30;7(3):e34587. doi: 10.1371/journal.pone.0034587

Figure 4. Bortezomib treatment affects cytokine production in DSS-induced colits.

Figure 4

Cytokine mRNA expression in the colon (A) and mesenteric lymph nodes (B) in mice treated with bortezomib or control during DSS-induced colitis. Colon tissue and mesenteric lymph nodes were collected from control- or bortezomib-treated mice 7 days following DSS administration. Transcript levels were quantified by real-time PCR analysis and were normalized with an internal control. Values represent means (± SEM) from ≥4 mice of each group. Significant differences between sample means are indicated; *P<0.05, **P<0.01. Results represent one of two independent experiments producing similar results.