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. 2012 Mar 30;7(3):e34552. doi: 10.1371/journal.pone.0034552

Figure 5. Loss of antigen expression in IFN-γ or IFN-γ-receptor-deficient, but not in STAT1-deficient animals.

Figure 5

(A) Upregulation of MHC class I and II expression in lymphomas arising in wild-type and in IFN-γ-receptor-deficient mice after inoculation of 291OVA cells. Values are given as a mean (± standard error of the mean) of fold-induction based on values obtained from 291OVA cells in culture (n = 13–22 animals per group). (B) Antigen expression was maintained in outgrowing lymphomas after inoculation of 291OVA cells in STAT1−/− mice, but was invariably lost after inoculation of 291OVA cells into wild-type, IFN-γ−/− and IFN-γ-receptor−/− mice and their heterozyogous littermates (compiled IFN-γ+/− and IFN-γR+/−) (n = 8–15, p = 0.01), comparison of GFP expression in the 291OVA cell line and in STAT1−/− recipients with that in all other recipients. Mean fluorescence intensity of GFP in outgrowing lymphomas as a surrogate marker for OVA expression.