Table 5.
Relative affinity of anthocyanins and phenolic acids for ERα and ERβ
| Compound | ERα IC50 (μM)* | ERβ IC50 (μM)* |
|---|---|---|
| Delphinidin-3-O-glucoside | NA | 63.2 ± 0.8 |
| Pelargonidin-3-O-glucoside | 61.3 ± 0.7 | 93.0 ± 0.8 |
| Peonidin-3-O-glucoside | 64.4 ± 0.9 | NA |
| Malvidin-3-O-glucoside | NA | NA |
| Cyanidin-3-O-glucoside | NA | NA |
| Gallic acid | NA | 100.3 ± 0.9 |
| Protocatechuic acid | NA | NA |
| Syringic acid | NA | NA |
| Vanillic acid | NA | NA |
* IC50 is defined as the concentration required to achieve 50% inhibition in the binding of [3H]-estradiol to the corresponding estrogen receptor (ER). NA not achieve binding at the assayed concentration. IC50 values are shown as mean ± SD