Table 4.

Correlation of serum Se and GPx activity by genotype of six selenoprotein genes

Gene	SNP	Genotype	N	serum Se (ng/ml)		GPx_activity1		Correlation
				Mean (SD)	Range	Mean (SD)	Range
GPx1	rs1050450	C/C	243	112.1 (1.2)	72.6–181.6	15.49 (7.24)	0.83–38.81	r = 0.151, P = 0.019
		C/T	219	110.7 (1.2)	63.2–195.0	13.40 (7.10)	0.83–37.57	r = 0.244, P = 0.0003
		T/T	40	111.2 (1.2)	64.0–222.7	13.56 (7.07)	2.07–34.27	r = 0.094, P = 0.564
SELS	rs28665122	A/A	7	92.6 (1.1)	75.8–102.6	10.44 (6.64)	3.72–21.88	r = 0.367, P = 0.418
		A/G	87	108.2 (1.2)	75.8–157.9	13.64 (7.93)	0.83–37.16	r = 0.215, P = 0.047
		G/G	275	108.5 (1.2)	65.5–157.9	13.72 (6.99)	0.83–37.48	r = 0.120, P = 0.049
SEPP1	rs3877899	A/A	24	107.1 (1.3)	75.8–195.0	12.97 (4.63)	4.96–26.84	r = 0.132, P = 0.539
		A/G	189	109.7 (1.2)	63.2–170.5	14.74 (7.24)	0.83–37.57	r = 0.222, P = 0.002
		G/G	285	113.0 (1.2)	65.5–222.7	14.39 (7.39)	0.83–38.81	r = 0.175, P = 0.003
SELS	rs4965373	A/A	57	112.2 (1.2)	79.0–195.0	14.39 (7.26)	2.07–38.81	r = 0.208, P = 0.124
		A/G	213	113.0 (1.2)	64.0–222.7	14.55 (6.97)	1.24–37.57	r = 0.217, P = 0.002
		G/G	232	109.8 (1.2)	63.2–195.0	14.32 (7.48)	0.83–37.48	r = 0.161, P = 0.015
SEP15	rs5845	C/C	315	111.1 (1.2)	63.2–222.7	14.20 (7.48)	0.83–38.81	r = 0.196, P = 0.0005
		C/T	172	111.9 (1.2)	72.6–195.0	14.67 (6.90)	0.83–35.92	r = 0.161, P = 0.036
		T/T	15	114.0 (1.2)	75.8–157.9	16.61 (4.76)	9.08–22.30	r = 0.416, P = 0.139
GPx4	rs713041	C/C	156	111.9 (1.2)	72.6–157.9	14.48 (8.03)	0.83–37.57	r = 0.206, P = 0.010
		C/T	241	110.4 (1.2)	63.2–222.7	14.22 (6.53)	0.83–37.16	r = 0.223, P = 0.0005
		T/T	105	113.3 (1.2)	79.0–195.0	14.83 (7.55)	2.89–38.81	r = 0.088, P = 0.374

Correlations are based on linear regression line fitting (Selenium = serum Se level, SD = standard deviation)

Bold values is statistically significant