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. 2012 Mar 13;3:735. doi: 10.1038/ncomms1734

Figure 2. Wnt-1 and Wnt-10b are upregulated in fibrotic diseases and Dkk-1 is downregulated.

Figure 2

(a) Confocal microscopy with double staining for Wnt-1 and vimentin demonstrated an overexpression of Wnt-1, in particular, in vimentin-positive cells in fibrotic skin of patients with SSc, in IPF and in liver cirrhosis. (b) Wnt-10b was also overexpressed in SSc, IPF and liver cirrhosis. (c) In parallel to the upregulation of Wnt-1 and Wnt-10b, a prominent decrease of the endogenous antagonist Dkk-1 was observed in fibroblasts in fibrotic diseases. Representative examples from 12 patients with SSc, 10 samples of non-fibrotic skin, 10 patients with IPF, 6 control lungs, 8 patients with liver cirrhosis and 8 control livers are shown. Scale bars, 20 or 5 μm for the outer right image of each panel, respectively.