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RNAi pathway. Endogenous miRNAs are transcribed as Pri-miRNAs that are subsequently processed by Drosha and Dicer to generate mature miRNAs. The guide strand is then incorporated into the RNA-induced silencing complex (RISC) to facilitate gene silencing. Reagents that have been developed for screening include expressed constructs (shRNA and shRNA-miR), as well as synthetic constructs: siRNA, miRNA mimics, and miRNA inhibitors.
