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Knockdown of Orai1 inhibits the resorption activity of OCLs. A) RAW cells infected with either control (left panel) or Orai1 shRNA (right panel) lentivirus were grown on the Ca2+-phosphate-coated plate in the presence of 100 ng/ml RANKL for 6 d. B, C) Both average number (B) and total area of pits (C) were measured as described in Materials and Methods. Data are means ± se of quadruplicate samples from 3 independent experiments. ***P < 0.001.
