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Vancomycin treatment confers cardioprotection within 48 h, and the effect is lost by 72 h after cessation of treatment. Vancomycin was added to the drinking water (60 mg/kg/d) before heart excision for ischemia/reperfusion studies. Food and (vancomycin) water were fed ad libitum to all rats. Data are means ± sd; n = 4. *P < 0.05 vs. control.
