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Diabetes reduces growth factor mRNA levels during resolution of periodontal inflammation, which is reversed by TNF inhibition. Induction and resolution of periodontal disease and application of TNF inhibitor were performed as in Fig. 1. RNA was isolated from periodontal tissue, and mRNA levels of TGFβ (A), BMP-2 (B), BMP-6 (C), and FGF-2 (D) were measured by real-time PCR. +P < 0.05 vs. diabetic group.
