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TNF inhibition enhances BMP-2 and FGF-2 production in the periodontium in diabetic specimens. Induction and resolution of periodontal disease and application of TNF inhibitor were performed as in Fig. 1. Numbers of BMP-2- and FGF-2-expressing cells in proximity to bone (within the periodontal ligament) were measured by immunohistochemistry using antibodies specific for BMP2 (A) and FGF-2 (B). *P < 0.05 vs. normoglycemic group; +P < 0.05 vs. diabetic group.
