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Schematic of RanBP9 in Aβ generation and focal adhesions. Binding of RanBP9 to β1-integin, LRP, and/or APP accelerates their endocytosis, thereby promoting Aβ generation and simultaneously disrupting focal adhesions. Although APP, LRP, and β1-integrin all form complexes with each other, it remains to be determined whether RanBP9 acts on the protein complex, individual proteins, or a combination thereof.
