Table 1.
The association between patients' demographic/clinical characteristics and plasma drug therapeutic concentration among patients on a stavudine-containing regimen in Uganda.
| Plasma drug concentration | Crude association | ||||
|---|---|---|---|---|---|
| Below normal range1 | Within or above normal range2 | Odds ratio (95%CI) | P-value | ||
|
| |||||
| Self-report Adherence | Below 95% (n = 40) | 26 (65.0%) | 14 (35.0%) | [reference] | <0.0001 |
| 95% and above (n = 194) | 42 (21.7%) | 152 (78.4%) | 6.72 (3.06, 14.78) | ||
|
| |||||
| Gender | Male (n = 84) | 23 (27.4%) | 61 (72.6%) | [reference] | 0.6728 |
| Female (n = 150) | 45 (30.0%) | 105 (70.0%) | 0.88 (0.49, 1.59) | ||
|
| |||||
| Age in years | Mean (SD) | 38.4 (7.0) | 38.6 (6.9) | 1.00 (0.96, 1.05) | 0.833 |
|
| |||||
| Employment status | Not Employed (n = 96) | 23 (24.0%) | 73 (76.0%) | [reference] | 0.2079 |
| Employed (n = 133) | 42 (31.6%) | 91 (68.4%) | 0.68 (0.38, 1.24) | ||
|
| |||||
| Marital Status | Not married (n = 106) | 24 (22.6%) | 82 (77.4%) | [reference] | 0.0496 |
| Married (n = 128) | 44 (34.4%) | 84 (65.6%) | 0.56 (0.31, 1.01) | ||
|
| |||||
| Education | No Education (n = 16) | 5 (31.3%) | 11 (68.8%) | [reference] | 0.8419 |
| Some Education (n = 218) | 63 (28.9%) | 155 (71.1%) | 1.12 (0.37, 3.36) | ||
| Alcohol drinking status | Never (n = 144) | 42 (29.2%) | 102 (70.8%) | [reference] | 0.7946 |
| Stopped drinking (n = 26) | 8 (30.8%) | 18 (69.2%) | 0.93 (0.37, 2.29) | ||
| Still drinking (n = 60) | 15 (25.0%) | 45 (75.0%) | 1.24 (0.62, 2.45) | ||
|
| |||||
| Current CD4 count in cells/mL | Mean (SD) | 289 (180) | 292 (141) | 1.00 (1.00, 1.00) | 0.916 |
|
| |||||
| Body weight in kgs | Mean (SD) | 61.9 (9.9) | 62.9 (10.0) | 1.01 (0.98, 1.04) | 0.520 |
1Stavudine plasma concentration below 36 nM/mL
2Stavudine plasma concentration 36 nM/mL and above.