Endotoxic shock |
PPARα/fenofibrate |
Decrease in coagulation activation (monocyte tissue factor expression), protection against endothelial dysfunction |
Not examined |
Wiel et al. [107] |
PPARγ/rosiglitazone |
Suppression of biomarkers for liver and kidney injury and of cytokines, inhibition of heart rate increase |
Not examined |
Wu et al. [110] |
PPARγ/15d-PGJ2 |
Improvement of survival rate, reduction of adhesion molecule expression, and of neutrophil infiltration in tissues |
NF-κB, HSP (heat shock protein) 70 |
Kaplan et al. [104] |
|
Hemorrhagic shock |
PPARγ/ciglitazone |
Amelioration of mean arterial pressure, reduction of plasma cytokine levels, decrease of apoptosis in lung and liver |
NF-κB |
Chima et al. [112] |
Caspase-3, PI3/Akt |
Chima et al. [113], Zingarelli et al. [105] |
PPARγ/15d-PGJ2 |
Attenuation of renal dysfunction and of liver, lung, and intestine injury |
Not examined |
Abdelrahman et al. [111] |
|
Polymicrobial sepsis/septic shock |
PPARβ/δ
|
Decrease in cytokine release, attenuation of organ dysfunction, reduced expression of inducible nitric oxide synthase |
Akt, GSK-3β, ERK1/2, STAT-3, NF-κB |
Kapoor et al. [106] |
Zingarelli et al. [115] |
PPARγ/ciglitazone and 15d-PGJ2 |
Amelioration of hypotension and survival, decreased inflammatory signs in lung, colon, and liver |
NF-κB, AP-1 |
Zingarelli et al. [114] |
|
Multiple organ failure |
PPARβ/δ
|
Reduction of peritoneal exsudate formation and of neutrophil infiltration, attenuation of multiple organ dysfunction syndrome |
Not examined |
Galuppo et al. [117] |
PPARγ/rosiglitazone |
Attenuation of peritoneal exsudation and of organ injury and dysfunction |
Not examined |
Cuzzocrea et al. [116] |