Table 3.
SNP | Position (Genome Build 36.3) | Gene | Familial PD GWAS P-values [32] | SNCA expression estimate | SNCA expression min P-value | Samplea/ Transcriptb/Modelc |
MAF in expression samples | A1/A2 |
---|---|---|---|---|---|---|---|---|
rs1560488 | 90,444,858 | GPRIN3 | 0.12 | 0.235 | 0.048 | C/T/rec | 0.229 | T/C |
rs4106153 | 90,463,499 | intergenic | 9.18 × 10−5 | −0.048 | 0.206 | All/T/add | 0.196 | C/A |
rs1504489 | 90,477,611 | intergenic | 8.42 × 10−5 | −0.124 | 0.089 | PD/T/rec | 0.425 | T/G |
rs924033 | 90,654,576 | intergenic | 0.02 | 0.165 | 0.041 | C/FL/add | 0.067 | G/T |
rs356229 | 90,825,620 | intergenic | 5.48 × 10−5 | −0.099 | 0.247 | C/FL/rec | 0.360 | C/T |
rs356219 | 90,856,624 | intergenic | *2.24 × 10−6 | 0.053 0.040 |
0.062 0.085 |
PD/FL/add All/FL/add |
0.391 | G/A |
rs356188 | 90,910,560 | SNCA | 8.41 × 10−5 | 0.062 | 0.063 | C/FL/add |
0.278 | C/T |
rs3775478 | 91,061,863 | MMRN1 | 6.07 × 10−5 | 0.035 0.017 |
0.672 0.672 |
C/T/add All/FL/add |
0.090 | G/A |