Figure 5.

Mutation signature and structural variations in HCC patients. (A) High confidence, somatic single-base substitutions were classified into all six categories of base substitutions. The fraction of mutations belonging to each category is shown for the four HCC patients, and compared to signatures previously found in NSCLC (Lee et al. 2010), SCLC (Pleasance et al. 2010b), melanoma (Pleasance et al. 2010a), and germline variations. (B) Number of predicted structural variations detected in both HBV positive and negative HCC patients. (Intra) Intrachromosomal SVs. (Inter) Interchromosomal SVs.