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. 2012 Apr 2;3:78. doi: 10.3389/fphys.2012.00078

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Copyright © 2012 Christ and Brückner.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

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Anti-apoptotic and pro-proliferative action of MSC after acetaminophen intoxication of the rat liver. Rats were treated with a repeated dose of 4 g/kg body weight of acetaminophen. Eighteen hours after the last dose the animals were sacrificed and the livers prepared for the detection of apoptotic cells (dark nuclei) by the TUNEL assay (lower panels) or proliferating cells (dark nuclei) by the Ki67 stain (upper panels). Where indicated animals received adipose tissue-derived rat MSC pre-differentiated into hepatocyte-like cells (rMSC-HC) 6 h after the last dose of acetaminophen. It is obvious that the number of apoptotic cells was significantly lower but of proliferating cells was higher in the livers with MSC (right panels) indicating the anti-apoptotic and pro-proliferative action of the MSC.