Table 1.
Summary of clinical trials involving mesenchymal stem cells of different tissue sources for the treatment of chronic liver diseases.
| Study Title | MSC source | Sponsor | Patients | Study phase | Status |
|---|---|---|---|---|---|
| Safety and efficacy of human mesenchymal stem cells for treatment of liver failure | Umbilical cord | Beijing 302 Hospital, China | 70 | Phase I/II | recruiting |
| Autologous mesenchymal stem cell transplantation in liver cirrhosis | No details | Gulhane Military Medical Academy, Turkey | 25 | No details | recruiting |
| Umbilical cord mesenchymal stem cells infusion via hepatic artery in cirrhosis patients | Umbilical cord | Qingdao University, China | 50 | Phase I/II | Not yet recruiting |
| Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: a phase I–II clinical trial | No details | Shaheed Beheshti Medical University, Islamic Republic of Iran | 30 | Phase I/II | Completed |
| Allogeneic bone marrow mesenchymal stem cells transplantation in patients with liver failure caused by hepatitis B virus | Bone marrow | Sun Yat-sen University, China | 120 | Phase II | Active, not recruiting |
| Human umbilical cord mesenchymal stem cells transplantation for patients with decompensated liver cirrhosis | Umbilical cord | Shenzhen Beike Bio-Technology Co., Ltd., China | 20 | Phase I/II | Completed |
| Human menstrual blood-derived mesenchymal stem cells for patients with liver cirrhosis | Menstrual blood | S-Evans Biosciences Co., Ltd., China | 50 | Phase I/II | Recruiting |
| Umbilical cord mesenchymal stem cell transfusion in patients with severe liver cirrhosis | Umbilical cord | Chinese Academy of Sciences, China | 200 | Phase I/II | Recruiting |
| Mesenchymal stem cells after renal or liver transplantation | No details | University Hospital of Liege, Belgium | 40 | Phase I/II | Recruiting |
| Therapeutic effects of liver failure patients caused by chronic hepatitis B after autologous MSCs transplantation | Bone marrow | Sun Yat-sen University, China | 158 | No details | Completed |
| Umbilical cord mesenchymal stem cells for patients with liver cirrhosis | Umbilical cord | Beijing 302 Hospital, China | 45 | Phase I/II | Recruiting |
| Efficacy of in vitro expanded bone marrow derived allogeneic mesenchymal stem cell transplantation via portal vein or hepatic artery or peripheral vein in patients with Wilson cirrhosis | Bone marrow | Murat Kantarcioglu, Gulhane Military Medical Academy, Turkey | 10 | Phase II | Recruiting |
| Transplantation of autologous mesenchymal stem cell in decompensate cirrhotic patients with pioglitazone | Bone marrow | Royan Institute, Islamic Republic of Iran | 3 | Phase I | Recruiting |
| Efficacy and safety study of allogenic mesenchymal stem cells for patients with chronic graft versus host disease | No comment | Chinese Academy of Medical Sciences, China | 100 | Phase II, phase III | Not yet recruiting |
| Efficacy and safety study of allogenic mesenchymal stem cells for patients with refractory primary biliary cirrhosis | Bone marrow | Robert Chunhua Zhao, Chinese Academy of Medical Sciences, China | 20 | Phase I | Not yet recruiting |
| Allogenic bone marrow stem cells transplantation in patients with liver cirrhosis | Bone marrow | Sun Yat-sen University, China | 60 | Phase II | Active, not recruiting |
| Allogenic bone marrow stem cell transplantation in liver failure | Bone marrow | Sun Yat-sen University, China | 60 | Phase II | Active, not recruiting |
Data are taken from reference (http://clinicaltrials.gov).