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. 2012 Apr;91(4):667–675. doi: 10.1189/jlb.1011510

Figure 2. Effect of donor-derived IL-10 on GVHD.

Figure 2.

(A) C3H.SW recipients were irradiated (10 Gy) on Day −1 and transplanted 5 × 106 syngeneic C3H.SW BM (▾; n=5), allogeneic B6(WT) 5 × 106 TCD BM + B6(WT) 1 × 106 CD25-depleted T cells (●; n=10), or B6(WT) 5 × 106 TCD BM + IL-10KO 1 × 106 CD25-depleted T cells (■; n=12). Data from one of two similar experiments are shown. ● versus ■, P = 0.4081. (B) C3H.SW recipients were irradiated (10 Gy) on Day −1 and transplanted 5 × 106 syngeneic C3H.SW BM (▾; n=5), allogeneic B6(WT) 5 × 106 TCD BM + B6(WT) 1 × 106 CD25-depleted T cells (●; n=10), or IL-10KO 5 × 106 TCD BM + B6(WT) 1 × 106 CD25-depleted T cells (■; n=10). Survival was monitored daily. Data from one of two similar experiments are shown. ● versus ■, P = 0.0785. (C) Day 24 pathology score of C3H.SW recipients received 1 × 106 allogeneic B6(WT) CD25-depleted T cells along with B6 (WT; n=4, black bar) or IL-10KO (n=4, gray bar) TCD BM. P = not significant. (D) B6D2F1 recipients were irradiated (11 Gy) on Day −1 and transplanted 5 × 106 syngeneic B6D2F1 BM (▾; n=11), allogeneic B6(WT) 5 × 106 TCD BM + B6(WT) 1 × 106 CD25-depleted T cells (●; n=15), or IL-10KO 5 × 106 TCD BM + B6(WT) 1 × 106 CD25-depleted T cells (■; n=15). Survival was monitored daily. Data from three similar experiments were combined and shown. ● versus ■, P = 0.7699.