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. 2012 Apr;91(4):667–675. doi: 10.1189/jlb.1011510

Figure 4. Donor Teff-derived IL-10 is not required for Treg-mediated suppression of GVHD.

Figure 4.

C3H.SW recipients were irradiated (10 Gy) on Day −1 and transplanted 5 × 106 syngeneic C3H.SW BM (▾; n=6), allogeneic B6(WT) 5 × 106 TCD BM + B6(WT) 1 × 106 CD25-depleted T cells (●; n=12), B6(WT) 5 × 106 TCD BM + B6(WT) 1 × 106 CD25-depleted T cells + B6(WT) 0.25 × 106 CD4+CD25+ T cells (○; n=7), B6(WT) 5 × 106 TCD BM + IL-10KO 1 × 106 CD25-depleted T cells (■; n=12), or B6(WT) 5 × 106 TCD BM + IL-10KO 1 × 106 CD25-depleted T cells + B6(WT) 0.25 × 106 CD4+CD25+ T cells (□; n=7). Survival was monitored daily. Data from two combined similar experiments are shown. ● versus ○, P = 0.0080; ■ versus □, P = 0.0080.