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. Author manuscript; available in PMC: 2012 Jul 17.
Published in final edited form as: Pharm Biol. 2010 Sep 7;49(1):15–25. doi: 10.3109/13880209.2010.492479

Table 2.

Acute toxicity of the decoction of the roots of Nauclea latifolia administered by intraperitoneal injection to mice.

Treatments Dose (mg/kg) Sex D/T Mortality latency (h) Toxic symptoms
Control - Male 0/5 - None
Femelle 0/5 - None
N. latifolia 100 Male 0/5 - None
Femelle 0/5 - None
N. latifolia 250 Male 0/5 - None
Femelle 0/5 - None
N. latifolia 500 Male 0/5 - None
Femelle 0/5 - None
N. latifolia 1000 Male 0/5 - None
Femelle 0/5 - Hypoactivity, piloerection
N. latifolia 2000 Male 1/5 >36, <48 Hypoactivity, piloerection, salivation, asthenia
Femelle 1/5 >36, <48 Hypoactivity, piloerection, salivation, asthenia
N. latifolia 4000 Male 3/5 >24, <36 Hypoactivity, piloerection, salivation, syncope
Femelle 2/5 >24, <36 Hypoactivity, piloerection, salivation, syncope
N. latifolia 8000 Male 5/5 >24, <36 Asthenia, anorexia, salivation, syncope
Femelle 5/5 >24, <36 Asthenia, anorexia, salivation, syncope

D/T = dead/treated mice; None = No toxic symptoms during the observation period; mortality latency = time to death (in days) after the intraperitoneal injection. The decoction of the roots of Nauclea latifolia was to group of mice. Mice in each group were carefully examined for any signs of toxic (behavioural changes and mortality) for 14 days. Control group received distilled water (10 ml/kg, i.p.).