Table 6.

Influence of the decoction of the roots of Nauclea latifolia on formalin-induced pain.

Treatments	Dose (mg/kg)	Licking time (s)		Inhibition (%)
		Early phase (0–5 min)	Late phase (15–30 min)	Early phase	Late phase
Control		73.3 ± 1.8	69.3 ± 2.9	-	-
N. latifolia	16	57.3 ± 3.7	55.2 ± 1.9	21.8*	20.4*
N. latifolia	40	48.2 ± 3.2	45.7 ± 1.3	34.3*	34.1*
N. latifolia	80	33.7 ± 2.3	33.3 ± 2.5	54.1**	51.9**
N. latifolia	160	28.8 ± 1.2	24.8 ± 2.1	60.7**	64.2***
Indomethacin	10	70.2 ± 1.5	22.8 ± 2.2	4.3	67.1***
Morphine	5	35.8 ± 2.2	18.7 ± 1.0	64.8***	73.1***
Theophylline + N. latifolia#	5 + 160	28.0 ± 1.6	25.2 ± 1.5	61.8***	63.7***
Glibenclamide + N. latifolia#	8 + 160	71.5 ± 1.8	68.5 ± 1.6	2.5	1.20
Naloxone + N. latifolia#	2 + 160	71.3 ± 4.0	68.2 ± 2.5	2.7	1.7
L-NAME + N. latifolia#	10 + 160	68,2 ± 1.8	68,5 ± 1.8	7.0	1.2

Results are expressed as mean ± S.E.M., the amount of time spent licking and biting the injected paw was indicative of pain and was recorded in 0–5 min (first phase) and 15–30 min (second phase), n = 6,

^*P<0.05,

^**P<0.01,

^***P<0.001, significantly different compared to the control group, data were analysis by two-way Anova, followed Tukey’s (HSD) multicomparaison test. L-NAME: N_ω-L-nitro-arginine methyl ester.

^#control is Nauclea latifolia at the dose of 160 mg/kg.