FIG. 3.

ITMs for the MAPK cascade part of the yeast pheromone response obtained by running the normalized channel mode with Ste20p as the source and Ste12p as the sink (μ = 0.85). In addition to the “standard” excluded nodes (histones, chaperones, cytoskeleton), we also removed the nodes for Slt2p and Nup53p as discussed in the main text. Gray shading of each node indicates its total content (darker nodes represent more visits). The number of nodes shown is determined by the participation ratio.