Figure 2.

Exposure to all topographically patterned surfaces decreases αSMA expression in rabbit corneal stromal cells. Expression is presented as the amount of αSMA relative to the planar surface at 10 ng/mL TGFβ. Cells grown on all topographically patterned surfaces demonstrated significantly reduced levels of αSMA compared with the planar surface when exposed to at least 1 ng/mL of TGFβ. Cells on the 1400 nm pitch surface expressed the lowest levels of αSMA, expressing 3.3-fold less than those on planar surfaces at 1 ng/mL TGFβ and 10.7-fold less αSMA at 10 ng/mL TGFβ. Error bars indicate SEM. **P < 0.005; ***P < 0.002.