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. 2012 Feb 22;53(2):952–958. doi: 10.1167/iovs.11-8526

Figure 2.

Figure 2.

Substratum stiffness impacts myocilin mRNA and cellular response to Lat-B treatment in HTM cells. Cells grown on stiff hydrogels and treated with DMSO had significantly different myocilin mRNA expression in comparison with DMSO-treated cells on TCP (>1 GPa) or more compliant hydrogels. Cells grown on hydrogels and treated with Lat-B had significantly less myocilin mRNA expression versus treatment with DMSO. In contrast, cells grown on TCP and treated with Lat-B had no significant difference in myocilin mRNA expression versus treatment with DMSO. Data are mean ± SEM for HTM 211 donor. (*P < 0.05 for hydrogel versus TCP; a,b,cP < 0.05 between the different hydrogels; †P < 0.05 for DMSO versus Lat-B).