Table 1.
Ontology analysis of the differentially expressed macrophage genes by Mtb infection
| Biological function | Number of differentially expressed genes | |||
|---|---|---|---|---|
| 6 hours | 24 hours | |||
| CDC1551 | HN878 | CDC1551 | HN878 | |
| Inflammatory response | 391 | 343 | 221 | 232 |
| Cellular growth and proliferation | 650 | 549 | 325 | 371 |
| Cell-to-cell signaling and interaction | 334 | 305 | 217 | 224 |
| Antigen presentation | 147 | 150 | 115 | 117 |
| Cell death | 512 | 455 | 243 | 279 |
| Cell cycle | 333 | 279 | 157 | 186 |
| DNA replication, recombination and repair | 212 | 141 | 54 | 69 |
| Gene expression | 507 | 399 | 161 | 178 |
| Small molecule biochemistry | 257 | 221 | 112 | 173 |
| Lipid metabolism | 211 | 188 | 112 | 150 |
Total host RNA was isolated from the BMM infected with Mtb CDC1551 or HN878 at 6 and 24 hpi and analyzed by microarray. The list of differentially expressed genes (at least 2 fold changes in expression levels and P ≤ 0.05) was uploaded into IPA software for functional analysis. The number of significantly differentially expressed host genes upon Mtb infection at 6 and 24 hpi and their respective biological function are shown.