Figure 6.
Inhibition of tumorigenicity by knockdown of NM23-H2. (A) Immunoblot analysis was performed for NM23-H2 knockdown in NM23-H2 expressed cells (HNM10 and HNM14). Stable transfectants were transduced with lentivirus containing NM23-H2 or non-target (NT) shRNA. (B) Inhibition of tumor growth in stable transfectants transduced with lentivirus. The left and the right shoulders of mice were inoculated with non-targeting (shNT-HNM10 and shNT-HNM14) and targeting transfectants (sh221s-HNM10 and shNM465s-HNM14), respectively. Tumor growth was measured after 30 days (n = 6).