Table 1.
Case summary and results of Urovysion analysis
| Case # | Age (years) | Gender | Grade | pT category (Invasiveness) | CEP3,7,17 | 9p21 | 9p21/CEP9 | |
|---|---|---|---|---|---|---|---|---|
| Single signal | No signal | |||||||
| 1 | 63 | M | Low | pTa (non-invasive) | 11 | 4 | 0 | 12 |
| 2 | 60 | F | 1 | 0 | 0 | 0 | ||
| 3 | 77 | M | 2 | 8 | 0 | 3 | ||
| 4 | 64 | M | 0 | 5 | 0 | 4 | ||
| 5 | 79 | M | 2 | 14 | 32 | 46 | ||
| 6 | 60 | M | High | pTa (non-invasive) | 49 | 19 | 12 | 39 |
| 7 | 77 | M | 3 | 2 | 0 | 2 | ||
| 8 | 64 | M | pT1 (focally invasive) | 34 | 10 | 0 | 7 | |
| 9 | 78 | M | 15 | 19 | 22 | 25 | ||
| 10 | 67 | F | pT1 (diffusely invasive) | 46 | 30 | 8 | 37 | |
| 11 | 46 | M | 40 | 2 | 43 | 48 | ||
| 12 | 75 | M | pT2 (diffusely invasive) | 42 | 1 | 44 | 46 | |
In total, samples were used from 12 patients. Details of patient age and gender, and the grade and invasiveness of their carcinoma are shown. Cells were analysed from each case sample for a number of FISH staining characteristics, including the expression of chromosome enumeration probes (CEPs) 3, 7 and 17; loss of one or both 9p21 loci, and the ratio of cells expressing 9p21 and CEP9. Shown are the numbers of cells (out of 50 cells per sample) showing each type of aberration. Boxes with light and dark grey background indicate aberrant results based on criteria of Vysis. Boxes with dark grey backgrounds exhibit aberrant results with complete loss of 9p21.