Table 1.
Information on the individual single-cycle viral yield experiments plotted in Figure 3
| (Label) Strain | Cell Type | MOIa | VUb | p* (VU/h) |
 (h) |
ref. |
|---|---|---|---|---|---|---|
| (A) A/Udorn/307/72 (H3N2) | A549 | 3 | PFU/mL | (8.2 ± 0.3) × 105 | 10.9 ± 0.8 | [28] |
| (B) A/Udorn/307/72 (H3N2)c | A549 | 3 | PFU/mL | (2.7 ± 0.6) × 105 | 12 ± 5 | [28] |
| (C) A/Udorn/307/72 (H3N2) | A549 | 5 | PFU/mL | (3.1 ± 0.9) × 106 | (6 ± 3) | [29] |
| (D) A/Udorn/307/72 (H3N2)d | A549 | 5 | PFU/mL | (2.6 ± 0.1) × 106 | 5.8 ± 0.4 | [29] |
| (E) A/Udorn/307/72 (H3N2) | MDCK | 5 | PFU/mL | (5.6 ± 0.3) × 106 | (6.1 ± 0.4) | [29] |
| (F) A/PR/8/34 (H1N1) | MDCK | 10 | TCID50/mL | (4 ± 1) × 103 | 6 ± 3 | [30] |
| (G) A/PR/8/34 (H1N1) | MDCK | 32 | PFU | (7.5 ± 0.4) × 105 | (9.8 ± 1) | [9] |
| (H) A/X-31 (H3N2) | Vera | 50 | TCID50/mL | (1.34 ± 0.01) × 106 | (3.75 ± 0.01) | [31] |
| (I) A/NWS/33 (H1N1) | 1-5C-4 | 50 | PFU/mL | (1.26 ± 0.07) × 105 | 10.8 ± 1 | [32] |
a — The number of cells used in each experiment was ~ 2 × 106 except for (F) and (G) which had 9 × 106 and 3 × 105 cells, respectively.
b — Virus Unit. It should be noted that this unit is inherently experiment-specific, depending on virus strain, cell type and experimental details. Quantities which depend on VU (e.g., p*) cannot be directly compared between experimental groups.
c — NS1-T215A recombinant mutant.
d — NS1-R38A recombinant mutant.