Table 4.
Constrained model fits to the human influenza infection data in Figure 6.
| A/Texas/36/91 (H1N1) [38] | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Dista | c (h–1) |  |
pb,c | τL (h) | σL | τI (h) | σI |
 (h) |
 (h) |
R0 | SSRd |
| exp | 0.19 | 0.022 | 280 | 5.4 | — | 16.9 | — | 3.7 | 11.7 | 89 | 1.00 |
| δ | 0.059 | 2.85 | 62 | 10.2 | — | 23.0 | — | 10.2 | 23.0 | 390 | 1.00 |
| N | 0.059 | 0.013 | 100 | 1.8 | (4.6 h)c | 12.1 | (9.7 h) | 3.9 | 13.4 | 240 | 0.98 |
| lnN | 0.059 | 0.72 | 99 | 8.7 | (0.49) | 14.5 | (0) | 8.7 | 14.5 | 250 | 1.00 |
| A/Bethesda/1/85 (H3N2) [39] | |||||||||||
| Dist | c (h–1) | V0 | p | τL (h) | σL | τI (h) | σI |
(h) |
(h) |
R0 | SSR |
| exp | 0.11 | 7.0 | 1.3 × 105 | 9.0 | — | 2.2 | — | 6.4 | 1.5 | 20 | 0.91 |
| δ | 0.10 | 28.4 | 7.7 × 103 | 9.9 | — | 31.5 | — | 9.9 | 31.5 | 320 | 0.88 |
| N | 0.10 | 10.6 | 1.2 × 104 | 9.6 | (4.6 h) | 19.9 | (9.7 h) | 9.7 | 20.1 | 200 | 0.90 |
| lnN | 0.10 | 11.8 | 8.0 × 103 | 8.5 | (0.49) | 30.4 | (0) | 8.5 | 30.4 | 300 | 0.91 |
a — Delay model used: exponential (exp), fixed (δ), normal (N), and lognormal (lnN).
b — Units of p are [V]·h–1, where [V] = TCID50/mL, the units of viral titer.
c — The value of pβ was held fixed at 1 h–2 for all fits; values in parentheses were also eld fixed.
d — SSR′ is the ratio of the SSR to that of the empirical fit.