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. 2001 Apr 24;98(9):5134–5139. doi: 10.1073/pnas.081068398

Figure 1.

Figure 1

BRCA1 N-terminal protein sequence (amino acids 1–78). A line diagram showing the domains of the BRCA1 protein is depicted at the top. The N-terminal sequence (amino acids 1–78) is represented below, as indicated by the dashed lines. The RING domain [residues 24–71 defined by comparison to the c-Cbl RING finger structure (11)] is bracketed. Numbers above individual amino acids denote the position of each residue. Filled circles indicate putative zinc-binding residues, filled squares represent cancer-predisposing mutations, and open squares represent unclassified variants. Amino acid substitutions found in patients are indicated below each residue. Circled residues denote the mutation analyzed (see also Table 1).