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. 2011 Oct 12;39(4 Suppl):73–81. doi: 10.2149/tmh.2011-S08

Table 3.

Genome expression of dengue infection

Population Subjects Sampling time Genes (abundant) expression associated with DI Gene expression associated with DSS Reference
1 Vietnamese adults 6 DSS: 8 non-DSS: 4 control (2nd) - Admission - A month later The ER stress response, cellular mitotic activity, B cell activation, innate immune response, apoptosis & oxygen transport. Increased B cell activation. Decreased ISGs, IFN-regulated, immune response. 45

2 Singapore adults 10 DF: 10 non-dengue - before day3 - day 7 - 3–4 weeks later NF-KB (IP-10), type I IFN (I-TAC) and ubiquitin proteasome. NA 51

3 Thai children 1 DSS: 3 DHF : 5 DF - Admission - A month later Metabolic and signal transduction, IFN-inducible and IFN-induced genes. Decreased both innate & acquired immune responses: cytokine/chemokine signaling molecule production, T and B cell activation, & killer cell activation. 52

4 Vietnamese (adult?) 9 DSS: 9 non-DSS - Day 4 - A month later Oxidative metabolism, interferon signaling, protein ubiquitination, apoptosis, and cytokines. Decreased apoptotic and type I IFN pathways. 9

5 Cambodian children 19 DSS: 13 DHF: 16 DF Decreased T, NK lymphocyte responses, increased anti-inflammatory, repair/remodeling transcripts, innate immunity, inflammation and lipid metabolism. 53

6 Singapore adults 31 DI: 26 non- den - before day3 - day 4–7 - 3–4 weeks later Innate immune response: IFN-signaling, pathogen recognition, and complement activation, biosynthesis, metabolism. Decreased T cell associated pathways. NA 54

Note: DF: dengue fever, DHF: dengue hemorrhagic fever, DSS: dengue shock syndrome, DI: dengue infection, 2nd: Secondary infection, ER: endoplasmic reticulum, ISGs: IFN-stimulated genes, NA: not applicable