Skip to main content
. 2012 Apr 2;7(4):e34504. doi: 10.1371/journal.pone.0034504

Figure 7. Critical Role of the NOX2 NADPH Oxidase isoform in neuronal damage and brain edema following TBI.

Figure 7

A: Confocal images show colocalization of the NOX2 NADPH oxidase isoform and NeuN in cerebral cortex at 1 h after TBI. B: Cresyl Violet staining and cell-counting studies showing neuroprotective effects of the NOX2 NADPH oxidase inhibitor, gp91ds-tat at 4 days after TBI. Note the enhanced neuronal density in the cerebral cortex in gp91ds-tat treated mice as compared to the scrambled-tat peptide control (Scr)-treated mice. Data are expressed as mean±SE, n = 5–7 in each group. *P<0.05 vs. scrambled-tat control. Scale bar, 50 µm. C: Brain water content was measured in the ipsilateral hemisphere at 1 day following TBI. Pretreatment with gp91ds-tat significantly reduced brain edema. Data are mean±SE (n = 12). *P<0.05 vs. scrambled-tat control.