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Orthogonal experimental design of [L16(45)].
| Therapeutic dose | Ischemia 1.0 h (A1) | Ischemia 1.5 h (A2) | Ischemia 2.0 h (A3) | Ischemia 2.5 h (A4) | Therapeutic dose |
|---|---|---|---|---|---|
| 5 mg/kg (B1) | 1.0 × 5 | 1.5 × 5 | 2.0 × 5 | 2.5 × 5 | 5 mg/kg (B1) |
| 10 mg/kg (B2) | 1.0 × 10 | 1.5 × 10 | 2.0 × 10 | 2.5 × 10 | 10 mg/kg (B2) |
| 20 mg/kg (B3) | 1.0 × 20 | 1.5 × 20 | 2.0 × 20 | 2.5 × 20 | 20 mg/kg (B3) |
| 40 mg/kg (B4) | 1.0 × 40 | 1.5 × 40 | 2.0 × 40 | 2.5 × 40 | 40 mg/kg (B4) |
