Table 2.

Genotype and allele frequencies of HLA-Bw4 and HLA-Bw6 in HIV-1-infected individuals with variable abilities to control viremia and in HIV-1-negative control individuals

HLA	Total	Genotypes									Alleles
		Bw4/Bw4	f	P	Bw4/Bw6	f	P	Bw6/Bw6	f	P	Bw4	Bw6	P
Controllers	20	10	0.5		5	0.25		5	0.25		0.62	0.38
Non-controllers	19	0	0	0.0004	11	0.57	0.05	8	0.33	0.3	0.29	0.71	<0.0001
HIV-1-negative	108	16	0.15	0.001	57	0.53	0.02	35	0.32	0.6	0.41	0.59	0.0001

The frequencies (f) of HLA-Bw4 and HLA-Bw6 in 20 individuals who control viremia (controllers), 19 individuals who do not control viremia (non-controllers), and 108 uninfected control (HIV-1-negative) individuals are shown. P values compare genotype and allele frequencies of controllers versus non-controllers and controllers versus HIV-1-negative individuals. The 108 uninfected controls are from a Caucasian database from New England. Two of the controller individuals were infected for an unknown duration on no antiretroviral therapy, but for at least 4 (C-10) or 2 (C-20) years with repeated viral loads that were undetectable by the most sensitive HIV-1 assay available at the time of testing. We note that, even if these two individuals are excluded from the analysis, the association between Bw4 homozygosity and control of viremia remains statistically significant. The frequency of HLA-Bw4 and HLA-Bw6 alleles that we found is reflective of their frequencies in other ethnic groups (41).