Table 3.

HLA-Bw4 is independently associated with the ability to maintain a normal CD4 count and to remain AIDS free

Model	Not adjusted for CCR5			Adjusted for CCR5
	RH	95% CI	P	RH	95% CI	P
Bw4/Bw4 vs. Bw4/Bw6 + Bw6/Bw6	0.43	0.21–0.87	0.02	0.39	0.18–0.85	0.02
Bw4/Bw4 vs. Bw6/Bw6	0.31	0.14–0.70	0.005	0.29	0.12–0.71	0.007
Trend across genotypes	0.34	0.16–0.72	0.004	0.35	0.16–0.77	0.009

Adjusted relative hazards (RH) for progression to CD4 count <500 or diagnosis of AIDS. Results are shown for 103 participants in the SFCCC who had well-defined dates of seroconversion and unambiguous HLA-B typing, but had not reached the endpoint when first evaluated. In model 1, Bw4 homozygotes are compared with the other two groups combined. In model 2, the Bw4/Bw4 and Bw6/Bw6 homozygote groups are compared. In model 3, the trend in risk from Bw6/Bw6 to Bw4/Bw6 to Bw4/Bw4 is examined. All estimated RH are adjusted for the presence of HLA-B8, -B27, -B35, -B51, and -B57 alleles. Characterization of the CCR5 status (wild-type or heterozygous for the variant CCR5) of these individuals is from Smith et al. (30), and relative hazards on the right are also adjusted for CCR5 heterozygosity. CI, confidence interval.