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The Aβ aggregation process. Aβ monomer self-assembles into low molecular weight oligomeric species that can give rise to either off-pathway oligomers or nuclei of an undetermined size. Nuclei, which arise within the rate-limiting step of the Aβ aggregation pathway, will increase in size to form high molecular weight oligomers, soluble aggregation intermediates, and finally the fibrillar aggregates that deposit in AD brain to yield amyloid plaques.
