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The binding of ligands with G-quadruplex (G4) inhibit the formation of cancer. (A) Mechanism of telomerase inhibition by G4 ligands. (B) Mechanism of drug-mediated interference of telomere capping by G4 ligands (Yang and Okamoto, 2010). hTR, RNA component of human telomerase; hTERT, telomerase reverse transcriptase.
